In electrospray ionization source hydrogen/deuterium exchange LC-MS and LC-MS/MS for characterization of metabolites
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چکیده
منابع مشابه
Quantification of Melittin in Iranian Honey Bee (Apis mellifera meda) Venom by Liquid Chromatography-electrospray Ionization-ion Trap Tandem Mass Spectrometry (LC-ESI-IT-MS/MS)
The current research aimed to quantify melittin (MEL) in Iranian honey bee (Apis mellifera meda) venom. To this end, a liquid chromatography-electrospray ionization-ion trap tandem mass spectrometry (LC-ESI-IT-MS/MS) approach was employed. Melittin is the main toxic peptide of honey bee venom with various biological and pharmacological activities. It was extracted with...
متن کاملLC-ESI-MS/MS : Liquid chromatography-electrospray ionization-ion-trap tandem mass spectrometry
s 39 40 Herbivorous insects can cause deep cellular changes to plant foliage following infestations depending on feeding 41 behavior. Here, a proteomic study was conducted to investigate green peach aphid (Myzus persicae Sulzer) 42 influence as a polyphagous pest on the defense response of Arabidopsis thaliana (L.) Heynh after aphid colony 43 set up on host plant (3 days). Analysis of about 574...
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spectrometry (LC–ESI-MS) method for determination of eperisone in human plasma using buflomedil as the internal standard (IS) is established. After being made alkaline with saturated sodium bicarbonate solution, plasma samples are extracted with a mixture of diethyl ether–cyclohexane (1:1, v/v) and separated by highperformance liquid chromatography on a reversed-phase C1 8 column with a mobile ...
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A rapid, simple, and sensitive electrospray LC/MS method has been developed for the quantitative analysis of cocaine and benzoylecgonine in urine using electrospray with the Agilent 1100 LC/MSD system. Urine samples were extracted using solid phase extraction cartridges, and the drug and metabolite were analyzed without derivatization using an isocratic separation and selected ion monitoring (S...
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In the present study, comprehensive stress testing of amlodipine (AM) was carried out according to International Conference on Harmonization (ICH) Q1A(R2) guideline. AM was subjected to acidic, neutral and alkaline hydrolysis, oxidation, photolysis and thermal stress conditions. The drug showed instability in acidic and alkaline conditions, while it remained stable to neutral, oxidative, light ...
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ژورنال
عنوان ژورنال: Journal of the American Society for Mass Spectrometry
سال: 2002
ISSN: 1044-0305,1879-1123
DOI: 10.1016/s1044-0305(02)00346-x